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For instance, network-based analyses of a Danshen (Salvia) multi-component formula identified nine key compounds collectively modulating 42 cardiovascular-related genes, highlighting how a mixtures efficacy arises from multi-target synergy (Li et al., 2011)

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Furthermore, the expression of DRP1 was upregulated, resulting in the fragmentation of mitochondria and exacerbated oxidative stress [269]